Reumatizam, Vol. 59 No. 2, 2012.
Stručni rad
Juvenile dermatomyositis
Lana Tambić Bukovac
; Dječja bolnica Srebrnjak, Zagreb, Hrvatska
Marija Perica
; Dječja bolnica Srebrnjak, Zagreb, Hrvatska
Mandica Vidović
; Dječja bolnica Srebrnjak, Zagreb, Hrvatska
Lovro Lamot
; Dječja bolnica Srebrnjak, Zagreb, Hrvatska
Miroslav Harjaček
; Dječja bolnica Srebrnjak, Zagreb, Hrvatska
Sažetak
Juvenile dermatomyositis is the most common idiopathic inflammatory myopathy in children, and presents a heterogeneous group of subacute, chronic and acute diseases of skeletal muscles. Its unique presentation is marked with characteristic skin rushes and progressive muscle weakness. JDM is clinically distinct from adult dermatomyositis, because it is a systemic vasculopathy not associated with malignancy and it often overlaps with other chronic childhood inflammatory diseases. Although immunopathology of JDM is complex, new studies are completing our knowledge of disease pathogenesis. Corticosteroids represent the first line therapy, afterwards combined with immunomodulatory drugs and biological agents. Better knowledge of the disease combined with modern treatment modalities resulted in reduced mortality rates and in much improved quality of life in patients with JDM.
Ključne riječi
juvenile dermatomyositis; idiopathic inflammatory myopathy; therapy
Hrčak ID:
124044
URI
Datum izdavanja:
25.10.2012.
Posjeta: 1.746 *