Izlaganje sa skupa

Systemic sclerosis - introductory lecture

Dušanka Martinović Kaliterna ; Odsjek za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Mislav Radić ; Odsjek za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska

Sažetak

The pathogenesis of systemic sclerosis (SSc) is complex and appears to involve endothelium, epithelium, fibroblasts and immunological mediators, resulting in dysregulated vascular remodelling and ultimately vasculopathy. Endothelial cell injury is an early and probably initiating event, but the precise aethyology remains unclear. Vascular damage and tissue fibrosis are widespread in SSc and largely account for the protean clinical manifestations and substantial morbidity and mortality. Current therapies are primarily immunomodulatory in nature. Effective therapy will require directly targeting the fibrotic process and will necessitate an improved understanding of the roles of individual cell types and their products in the development of fibrosis.

Ključne riječi

vascular damage; vasculopathy; fibroblasts; fibrosis; systemic sclerosis

Hrčak ID:

124630

URI

https://hrcak.srce.hr/124630

Datum izdavanja:

14.10.2010.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.181 *