Reumatizam, Vol. 57 No. 1, 2010.
Stručni rad
Nonsteroidal anti-inflammatory drugs and the risk of cardiovascular diseases
Anita Jukić
; Zavod za kardiovaskularne bolesti, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Dušanka Martinović Kaliterna
; Odsjek za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Mislav Radić
; Odsjek za kliničku imunologiju i reumatologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Sažetak
Non-steroidal anti-inflammatory drugs act as non-selective inhibitors of the enzyme cyclooxygenase (catalyzes the formation of prostaglandins), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. Selective COX-2 inhibitors have reduced gastrointestinal related adverse events but increased the risk of cardiovascular diseases. Selective COX-2 inhibitors may tip the natural balance between prothrombotic thromboxane A2 and antithrombotic prostacyclin potentially increasing the possibility of a thrombotic cardiovascular event. Decreased prostacycline synthesis, a vasodilatator and modulator of platelet activation, contributing to platelet aggregation and vasoconstriction. Some studies have suggested that NSAID increase the risk of cardiovascular events and for patients at high cardiovascular risk we should use them with great caution.
Ključne riječi
non-steroidal anti-inflammatory drugs; cyclooxygenase; prostacycline; cardiovascular risk
Hrčak ID:
124783
URI
Datum izdavanja:
1.7.2010.
Posjeta: 1.624 *