Veterinarski arhiv, Vol. 84 No. 4, 2014.
Izvorni znanstveni članak
The pharmacokinetics of eprinomectin in sheep following subcutaneous administration.
Chirag M. Modi
orcid.org/0000-0002-2895-4469
; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry,Junagadh Agriculture University, Junagadh, Gujarat, India
Shailesh K. Modi
; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Sardarkrushinar Dantiwada Agriculture University, Sardarkrushinagar, North Gujarat, Dantiwada, India
Hitesh B. Patel
; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Sardarkrushinar Dantiwada Agriculture University, Sardarkrushinagar, North Gujarat, Dantiwada, India
Sažetak
The pharmacokinetics of eprinomectin was determined in lactating sheep following subcutaneous administration at a dose rate of 0.2 mg kg-1. The eprinomectin concentration in plasma was determined using High Performance Liquid Chromatography (HPLC) with a fluorescence detector. The kinetics of plasma concentrations were analysed using the non-compartment model. The maximum plasma concentration of 24.44 ng/mL occurred 2 days post-administration. Following subcutaneous administration of eprinomectin in sheep, the value of plasma elimination half-life, the area under the plasma concentration time curve (AUC) and mean residence time (MRT) were 388.52 ± 0.25 h. 4282.10 ng.h/mL and 374.50 h, respectively. The values of V (area), Vd(ss) and Cl(B) were 20.50 mL/kg, 13.70 mL/kg and 0.04 mL/h/kg, respectively. This study demonstrates that subcutaneous administration of eprinomectin led to higher bioavailability and longer mean residence time with a lower dose than a pour-on application, and that an injectable formulation may be applied in lactating sheep with zero withdrawal period.
Ključne riječi
eprinomectin; pharmacokinetics; subcutaneous administration; lactating sheep
Hrčak ID:
125063
URI
Datum izdavanja:
16.7.2014.
Posjeta: 1.990 *