Reumatizam, Vol. 51 No. 1, 2004.
Izvorni znanstveni članak
The distribution of HLA alleles class I and class II among patientes with psoriatic arthritis in Croatia
Zorana Grubić
; Zavod za tipizaciju tkiva, Klinika za urologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Porin Perić
; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Esma Čečuk-Jeličić
; Zavod za tipizaciju tkiva, Klinika za urologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Renata Žunec
; Zavod za tipizaciju tkiva, Klinika za urologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Božidar Ćurković
; Klinika za reumatske bolesti i rehabilitaciju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Vesna Kerhin-Brkljačić
; Zavod za tipizaciju tkiva, Klinika za urologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Sažetak
The aim of the present study was to analyze the distribution of HLA-A, -B, -Cw, and -DRB1 alleles among patients with psoriatic arthritis (PsA) in Croatia. DNA was isolated from peripheral blood of 58 PsA patients (28 male and 30 female) and tested by PCR-SSP (Polymerase Chain Reaction - Sequence Specific Primers) method for polymorphism of the above mentioned HLA loci. The strongest association between psoriatic arthritis and HLA in the Croatian population was observed for alleles at HLA-B locus (B*39 and B*57), while the association of B*27 and B*13 alleles with PsA reached significance only before correction of p value with the number of tested alleles. Higher frequency of Cw*02 and DRB1*16 alleles is a result of linkage disequilibrium between these alleles and HLA-B alleles associated with PsA in Croatia. We also observed lower frequency of B*0702, B*18 and B*38 alleles in our group of patients.
Ključne riječi
HLA; psoriatic arthritis; population study; Croatia
Hrčak ID:
126024
URI
Datum izdavanja:
1.8.2004.
Posjeta: 5.897 *