Pregledni rad

DYSLIPIDEMIA AND STROKE IN PATIENTS WITH CHRONIC KIDNEY DISEASE

PETAR KES ; Klinički bolnički centar Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Klinika za unutarnje bolesti, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
VANJA BAŠIĆ-KES ; Klinički bolnički centar Sestre milosrdnice, Stomatološki fakultet Sveučilišta u Zagrebu, Klinika za neurologiju, Zagreb, Hrvatska
VESNA FURIĆ-ČUNKO ; Klinički bolnički centar Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Klinika za unutarnje bolesti, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
INES MESAR ; Klinički bolnički centar Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Klinika za unutarnje bolesti, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
NIKOLINA BAŠIĆ-JUKIĆ ; Klinički bolnički centar Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Klinika za unutarnje bolesti, Zavod za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska

Sažetak

Altered lipid and lipoprotein metabolism occurs in patients with chronic kidney disease (CKD). Dyslipidemia persists in patients on chronic hemodialysis or peritoneal dialysis and even in renal transplant recipients, and contributes to accelerated atherosclerosis but may also contribute to the progression of kidney disease as well. The etiologies of altered lipid profile in patients with CKD, dialysis, and renal transplant recipients are complex because there are profound changes in the structure and function of lipoprotein and lipid molecules, which lead to accelerated atherosclerosis, cardiovascular disease and stroke. Cardiovascular disease and stroke are the major cause of morbidity and mortality in patients with impaired renal function. In this review, the pathogenesis and treatment of CKD-induced dyslipidemia are discussed. Studies on lipid abnormalities in predialysis, hemodialysis and peritoneal dialysis patients are analyzed. In addition, results of the studies that tested the effects of hypolipidemic drugs on stroke morbidity and mortality in patients with CKD are reported.

Ključne riječi

dyslipidemia; chronic kidney disease; stroke; hemodialysis; peritoneal dialysis; renal transplantation

Hrčak ID:

126806

URI

https://hrcak.srce.hr/126806

Datum izdavanja:

14.9.2014.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.385 *