Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2014.55.27
Eicosapentaenoic acid in serum lipids could be inversely correlated with severity of clinical symptomatology in Croatian war veterans with posttraumatic stress disorder
Dubravka Kalinić
; Department of Psychiatry and Psychological Medicine, University of Zagreb School of Medicine, Zagreb, Croatia
Leda Borovac Štefanović
; Department of Chemistry and Biochemistry, University of Zagreb School of Medicine, Zagreb, Croatia
Ana Jerončić
; Department for Research in Biomedicine and Health, University of Split School of Medicine, Split, Croatia
Ninoslav Mimica
; Department of Psychiatry and Psychological Medicine, University of Zagreb School of Medicine, Zagreb, Croatia
Goran Dodig
; Department of Psychiatry University Hospital Split, University of Split School of Medicine, Split, Croatia
Ivančica Delaš
orcid.org/0000-0002-0954-2813
; Department of Psychiatry University Hospital Split, University of Split School of Medicine, Split, Croatia
Sažetak
Aim To explore the association between plasma fatty acids
composition and the severity of clinical symptoms in
Croatian war veterans with posttraumatic stress disorder
(PTSD).
Methods This cross-sectional study included 62 men diagnosed
with PTSD caused by combat activities during
the War in Croatia 1991-1995. Clinician-Administered PTSD
Scale (CAPS), Hamilton Anxiety Rating Scale (HAM-A), and
Hamilton Depression Rating Scale (HAM-D-17) were used.
Plasma fatty acids composition was determined by gas
chromatography. Data about life-style habits were collected
by a structured interview. To evaluate the association
between plasma fatty acid levels and PTSD severity scales,
multivariate general linear models (GLM) were applied
while controlling for different confounders.
Results Significant negative correlations were found between
plasma eicosapentaenoic acid (EPA, 20:5n-3) level
and the scores on psychological scales (τ = -0.326, P < 0.001
for CAPS; τ-0.304, P = 0.001 for HAM-A; and τ = -0.345,
P < 0.001 for HAM-D-17). GLM confirmed that PTSD severity
was affected by EPA (Wilks’Λ = 0.763-0.805, P = 0.006-0.018,
ηp 0.195-0.237), arachidonic acid (AA)/EPA (Wilks’Λ = 0.699-
0.757, P = 0.004, ηp 0.243-0.301), and dairy products consumption
(Wilks’Λ = 0.760-0.791, P = 0.045-0.088, ηp 0.128-
0.111). No other fatty acid or dietary/lifestyle variable was
significant ( P = 0.362-0.633).
Conclusion The study suggests that lower EPA levels are
associated with the severity of clinical symptoms in PTSD.
Ključne riječi
Hrčak ID:
127271
URI
Datum izdavanja:
15.2.2014.
Posjeta: 1.113 *