Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2014.55.146
Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus
Tomislava Skuhala
orcid.org/0000-0003-0129-1519
; University Hospital for Infectious Diseases “Fran Mihaljević,” Zagreb,Croatia
Vladimir Trkulja
; Department of Pharmacology, Zagreb University School of Medicine, Zagreb, Croatia
Mislav Runje
; TAPI Research and Development Analytics, Pliva Croatia, Zagreb, Croatia
Dalibor Vukelić
; University Hospital for Infectious Diseases “Fran Mihaljević,” Zagreb,Croatia
Boško Desnica
; University Hospital for Infectious Diseases “Fran Mihaljević,” Zagreb,Croatia
Sažetak
Aim To investigate the relationship between plasma and
cyst concentrations of albendazolesulphoxide (ASO) and
their effects on parasitological findings and disease recurrence
in patients with liver hydatidosis.
Methods The study was conducted at the University Hospital
for Infectious Diseases “Dr. Fran Mihaljević,” Zagreb,
Croatia, between August 2006 and January 2011. Consecutive
patients (N = 48, age 6-77 years) were treated with
albendazole (3 × 5 mg/kg/d) over 28 days before surgical
cyst removal (n = 34) or percutaneous evacuation (PAIR)
(n = 14). Plasma ASO was determined on days 10 and 28 of
treatment and cyst concentrations at surgery/PAIR.
Results Disease recurred in 3 surgically treated patients.
Variability of ASO concentrations was substantial. Plasma
concentrations on day 10 were higher than on day
28 (geometric means ratio [GMR] 2.00; 95%CI 1.38-2.91,
P < 0.001) and higher than cyst concentrations at the time
of treatment (GMR = 1.58, 1.01-2.34, P = 0.045). Higher cyst
(but not plasma) concentrations were independently associated
with lower odds of protoscolex motility (OR = 0.23,
0.01-0.70, P < 0.001) and higher odds of protoscolex destruction
(OR = 1.17, 1.04-1.46, P < 0.001). With adjustment
for age and protoscolex motility, higher day 10 plasma
concentrations (but not cyst concentrations) were associated
with lower odds of disease recurrence (OR = 0.49,
0.09-0.97, P = 0.035). Plasma concentrations did not predict
cyst concentrations.
Conclusion Viability of protoscolices progressively decreased
with increasing ASO concentrations in the cyst.
Data strongly suggested that higher plasma concentrations
reduced the risk of disease recurrence.
Ključne riječi
Hrčak ID:
127310
URI
Datum izdavanja:
15.4.2014.
Posjeta: 1.009 *