Izvorni znanstveni članak
Importance of Interleukin 6 in Pathogenesis of Inflammatory Bowel Disease
Boris Takač
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinical Department of Nuclear Medicine and Radiation Protection, Osijek, Croatia
Silvio Mihaljević
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Division of Gastroenterology, Internal Clinic, Osijek, Croatia
Mario Štefanić
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Clinical Department of Nuclear Medicine and Radiation Protection, Osijek, Croatia
Ljubica Glavaš-Obrovac
; »J. J. Strossmayer« University, School of Medicine, Osijek, Croatia
Aleksandar Kibel
; »J. J. Strossmayer« University, University Hospital Centre Osijek, Division of Gastroenterology, Internal Clinic, Osijek, Croatia
Marina Samardžija
; J. J. Strossmayer« University, University Hospital Centre Osijek, Department of Transfusion Medicine, Osijek, Croatia
Sažetak
Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), is an uncontrolled chronic inflammation of the gastrointestinal tract caused by an interaction of diverse genes and environmental factors. There is growing evidence that cytokine production plays an important role in IBD. One of the key roles in signaling pathway in development of IBD is performed by interleukin 6 (IL-6), although molecular mechanism of this pathway is not yet fully understood. In order to assess the clinical relevance of IL-6 serum concentration in patients with CD and UC we performed cross-sectional, case-control study of IL-6 levels in patients’ and healthy blood donors’ sera. A total of 100 CD and UC patients and 71 healthy blood donors were investigated. Clinical activity of CD and UC was evaluated using the Crohn's disease activity index and Truelove-Witt's criteria, respectively. Quantitative assessment of serum IL-6 was performed with solid-phase, enzyme-labeled, chemiluminescent sequential immunometric assay. Our results indicate that serum IL-6 is a clinically relevant parameter for CD and UC that strongly correlates with inflammatory activity of disease. We confirmed and extended the role of cytokine production patterns for IBD presentation in Croatian population.
Ključne riječi
Interleukin 6; ulcerative colitis; Crohn’s disease; C-reactive protein; signal transducer and activator of transcription; T cells; soluble interleukin 6 receptor; membrane bound interleukin 6 receptor; proinflammatory cytokines; Crohn’s disease activity index
Hrčak ID:
127605
URI
Datum izdavanja:
30.6.2014.
Posjeta: 1.634 *