Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2014.55.299
Embryonic cerebrospinal fluid in brain development: neural progenitor control
Angel Gato
; Departament of Anatomy and Radiology, Faculty of Medicine Valladolid University, Valladolid Spain
M. Isabel Alonso
; Departament of Anatomy and Radiology, Faculty of Medicine Valladolid University, Valladolid Spain
Cristina Martín
; Departament of Anatomy and Radiology, Faculty of Medicine Valladolid University, Valladolid Spain
Estela Carnicero
; Laboratory of Nervous System Development and Teratology, Institute of Neurosciences of Castilla y León (INCYL), Valladolid University, Valladolid, Spain
José Antonio Moro
; Laboratory of Nervous System Development and Teratology, Institute of Neurosciences of Castilla y León (INCYL), Valladolid University, Valladolid, Spain
Aníbal De la Mano
; Laboratory of Nervous System Development and Teratology, Institute of Neurosciences of Castilla y León (INCYL), Valladolid University, Valladolid, Spain
José M. F. Fernández
; Departament of Cellular Biology Histology and Pharmacology Faculty of Medicine, Valladolid University, Valladolid, Spain
Francisco Lamus
; Departament of Anatomy and Radiology, Faculty of Medicine Valladolid University, Valladolid Spain
Mary E. Desmond
; Department of Biology, Villanova University, Villanova, PA, USA
Sažetak
Due to the effort of several research teams across the
world, today we have a solid base of knowledge on the
liquid contained in the brain cavities, its composition, and
biological roles. Although the cerebrospinal fluid (CSF) is
among the most relevant parts of the central nervous system
from the physiological point of view, it seems that it
is not a permanent and stable entity because its composition
and biological properties evolve across life. So, we can
talk about different CSFs during the vertebrate life span.
In this review, we focus on the CSF in an interesting period,
early in vertebrate development before the formation
of the choroid plexus. This specific entity is called “embryonic
CSF.” Based on the structure of the compartment,
CSF composition, origin and circulation, and its interaction
with neuroepithelial precursor cells (the target cells)
we can conclude that embryonic CSF is different from the
CSF in later developmental stages and from the adult CSF.
This article presents arguments that support the singularity
of the embryonic CSF, mainly focusing on its influence
on neural precursor behavior during development and in
adult life.
Ključne riječi
Hrčak ID:
129845
URI
Datum izdavanja:
15.8.2014.
Posjeta: 1.426 *