Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2014.55.306
The embryonic bloodcerebrospinal fluid barrier function before the formation of the fetal choroid plexus: role in cerebrospinal fluid formation and homeostasis
David Bueno
; Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain
Maryam Parvas
; Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain
Jordi Garcia-Fernàndez
; Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain
Sažetak
Cerebrospinal fluid (CSF) has attracted interest as an active
signaling milieu that regulates brain development,
homeostasis, and course disease. CSF is a nutrient-rich fluid,
which also contains growth factors and signaling molecules
that regulate multiple cell functions in the central
nervous system (CNS). CSF constitution is controlled tightly
and constituent concentrations are maintained narrow,
depending on developmental stage. From fetal stages to
adult life, CSF is produced mainly by the choroid plexus.
The development and functional activities of the choroid
plexus, and other blood-brain barrier systems in adults,
have been extensively analyzed. However, the study of CSF
production and homeostasis in embryos from the closure
of the anterior neuropore, when the brain cavities become
physiologically sealed, to the formation of the functional
fetal choroid plexus has been largely neglected. This developmental
stage is characterized by tightly controlled morphological
and cellular events in the anterior part of the
CNS, such as rapid brain anlagen growth and initiation of
primary neurogenesis in the neural progenitor cells lining
the cavities, events which are driven by specific molecules
contained within the embryonic CSF. In this article, we review
the existing literature on formation and function of
the temporary embryonic blood-CSF barrier, from closure
of the anterior neuropore to the formation of functional
fetal choroid plexuses, with regard to crucial roles that embryonic
CSF plays in neural development.
Ključne riječi
Hrčak ID:
129937
URI
Datum izdavanja:
15.8.2014.
Posjeta: 1.211 *