Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2014.55.498
Determination of the effects of pulmonary arterial hypertension and therapy on the cardiovascular system of rats by impedance cardiography
Belgin Buyukakilli
; Department of Biophysics, Faculty of Medicine, Mersin University Mersin, Turkey
Serkan Gurgul
; Department of Biophysics, Faculty of Medicine, GaziosmanpasaUniversity, Tokat, Turkey
Derya Cıtırık
; Department of Pediatric Cardiology, Faculty of Medicine, Mersin University, Mersin, Turkey
Murat Ozeren
; Department of Cardiovascular Surgery, Faculty of Medicine, Mersin University, Mersin, Turkey
Bahar Tasdelen
; Department of Biostatistics, Faculty of Medicine, Mersin University, Mersin, Turkey
Sažetak
Aim To evaluate the effects of bosentan, sildenafil, and
combined therapy on the cardiovascular system using impedance
cardiography (ICG) in rats with monocrotaline
(MCT)-induced pulmonary arterial hypertension (PAH).
Methods Seventy male Wistar-albino rats were randomized
into five groups. A single dose of MCT was given to all
rats, except to the control group. After 4 weeks, bosentan,
sildenafil, and combined treatment was started and lasted
for 3 weeks. The last group that developed PAH did not receive
any medication. Echocardiographic evaluation was
performed to determine the PAH development. Thoracic
fluid content index (TFCI), stroke volume index (SI), heart
rate (HR), cardiac index (CI), and myocardial contractility index
(IC) were determined. All procedures were performed
at the baseline and after 4 and 7 weeks.
Results Echocardiographic parameters showed that the
all MCT-injected rats developed PAH. There were no significant
inter- and intra-group differences in TFCI, SI, and
IC (P > 0.05), but at the 7th week, CI value in the sildenafil-
treated PAH rats was significantly higher than in other
groups and HR of PAH rats with combined therapy was significantly
lower than in other groups.
Conclusion PAH did not have an effect on LV function of
rats, or if it did, the effect was compensated by physiological
processes. Also, sildenafil treatment deteriorated the LV
cardiac index.
Ključne riječi
Hrčak ID:
129953
URI
Datum izdavanja:
15.10.2014.
Posjeta: 930 *