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The effects of intra-articular tramadol administration on histopathological indices in rat knee joints.

Rahmat A. Fatahian Dehkordi ; Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
Amin Bigham-Sadegh ; Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
Naser Vajdi ; Postgraduate of University of Shahrekord, Shahrekord, Iran


Puni tekst: engleski pdf 229 Kb

str. 667-676

preuzimanja: 459

citiraj


Sažetak

The aim of this study was to investigate the effect of intra-articular injections of saline and tramadol on the articular cartilage in rat knee joints. Twenty-five adult Wistar rats were used in this experiment. They were randomly assigned to two groups, control (n = 5) and experimental (n = 20) and the latter was subdivided into four groups (each group n = 5). Saline was administered intra-articularly into the knee joints in the controls (group 1) and tramadol with different doses was injected into the knee joints of the experimental groups. In groups 2, 3, 4 and 5 different concentrations, 0.1, 0.25, 1.0 and 2.5 mg/mL respectively, of available tramadol were administrated intra-articularly into the knee joints. The results showed that there were no pathological changes in the saline-treated control joints (P>0.05). Joints treated with tramadol displayed significantly more pathological changes than the saline joints (P<0.05). Group 5 (2.5 mg/mL) showed maximum pathological changes as compared to the other treatment groups and saline injection. Histological results in all parameters showed that there was no significant difference between joints that received tramadol in group 2, compared to saline-treated joints (P>0.05). Joints that received tramadol in group 3 (0.25 mg/mL) showed no significant difference as compared with control joints in all histological indices, except for cell count. Joints treated with tramadol in groups 4 and 5 revealed significant histological changes compared to control joints in all histological indices. We conclude that intra-articular tramadol in high dosages (especially 2.5 mg/mL) causes histopathological changes in rat knee joints.

Ključne riječi

histopathology, knee joint, rat, saline, tramadol

Hrčak ID:

130430

URI

https://hrcak.srce.hr/130430

Podaci na drugim jezicima: hrvatski

Posjeta: 798 *