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Synthesis and Characterization of Two Novel Zinc(II) Complexes with Ciprofloxacin. Crystal Structure of [C17H19N3O3F]2 ⋅ [ZnCl4] ⋅ 2H2O

Marija Zupančič ; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, POB 537, 1000 Ljubljana, Slovenia
Iztok Turel ; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, POB 537, 1000 Ljubljana, Slovenia
Peter Bukovec ; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva 5, POB 537, 1000 Ljubljana, Slovenia
Andrew J. P. White ; Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, UK SW7 2AY
David J. Williams ; Department of Chemistry, Imperial College of Science, Technology and Medicine, South Kensington, London, UK SW7 2AY


Puni tekst: engleski pdf 160 Kb

str. 61-74

preuzimanja: 636

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Sažetak

The complexation of ZnII ions with quinolone in aqueous solution depends mainly upon pH. To investigate the pH dependence of the complexation between ZnII and the quinolone derivative Ciprofloxacin (abbreviation cfH), UV-Vis spectroscopy was used. The crystal structure of the compound [C17H19N3O3F]2 ⋅ [ZnCl4] ⋅ 2H2O (compound I) was determined by X-ray diffraction, which showed the structure to be ionic, consisting of a tetrachlorozincate(II) dianion and two protonated, monocationic Ciprofloxacin molecules. Compound II ([Zn(cf)2] ⋅ 3H2O) was obtained as microcrystals from an aqueous solution of Ciprofloxacin hydrochloride and zine sulphate adjusted to pH = 8 by the addition of sodium hydroxide. Both complexes were characterized by elemental analysis, mass speetrometry, TG analysis and IR spectroscopy. From the analysis of these results we have proposed a probable mode of bonding for the complexation of ZnII to Ciprofloxacin in compound II.

Ključne riječi

fluoroquinolone, metal-ion complexation, Ciprofloxacin, zinc

Hrčak ID:

131772

URI

https://hrcak.srce.hr/131772

Posjeta: 1.028 *