Izvorni znanstveni članak

Accumulation Dynamics of the Brain Total Free Fatty Acids and Free Arachidonic Acid in the Models of Cerebral Hypoxia and Epilepsy in Rats

Gordana Župan ; Department of Pharmacology, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia
Jadranka Varljen ; Department of Chemistry and Biochemistry, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia
Vesna Eraković ; Department of Pharmacology, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia
Jasenka Mršić ; Department of Pharmacology, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia
Jasna Križ ; Department of Pharmacology, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia
Ante Simonić ; Department of Chemistry and Biochemistry, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia
Čedomila Milin ; Department of Chemistry and Biochemistry, Medical School, University of Rijeka, Braće Branchetta 20/1, HR-51 000 Rijeka, Croatia

Sažetak

The aim of this study was to determine the dynamics of the brain free fatty acid (FFA) pool in rats exposed to: (a) controlled hypoxia, and (b) experimental epilepsy. Animals from group (a) were subjected to hypoxia procedure. Immediately, 5,15 or 60 minutes after losing the righting reflex, the animals were decapitated and brains were quickly removed. Animals from group (b) received penicillin (5000 U/5 pi) into the left lateral ventricle and were decapitated immediately, 5 or 15 minutes after the appearance of epileptic seizures. The FFA were quantified by gas chromatography. An increase in the total brain FFA content with the maximum level at 60 minutes after losing the righting reflex was detected in hypoxia- exposed rats. The highest level of the brain free arachidonic acid (FAA) was detected 15 minutes after hypoxia. Seizures also produced an increase in the total brain FFA and brain FAA, with a statistically significant level 5 minutes after the appearance of epileptic seizures.

Ključne riječi

Hrčak ID:

136709

URI

https://hrcak.srce.hr/136709

Datum izdavanja:

1.9.1995.

Posjeta: 634 *