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Evoked Potentials in Diabetic Syndrome of Rats Before and After Two Months of Methadone Treatment

Milica Bjegović ; Department of Experimental Biology and Medicine, Rugjer Bošković Institute, Bijenička c. 54, HR-10 000 Zagreb, Croatia
Velimir Išgum ; Department of Neurology, Clinical Medical Center, Kispatićeva 12, HR-10 000 Zagreb, Croatia
Milivoj Slijepčević ; Department of Experimental Biology and Medicine, Rugjer Bošković Institute, Bijenička c. 54, HR-10 000 Zagreb, Croatia


Puni tekst: engleski pdf 14.265 Kb

str. 521-531

preuzimanja: 213

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Sažetak

The effect of two months treatment with methadone (0.87 mg/kg per os, daily) on the somatosensory evoked potentials (SEPs) in female control and diabetic rats were studied. Diabetes was induced by alloxan monohydrate (65 mg/kg i. v.). SEPs obtained after electrical stimulation of the contralateral forepaw and recorded from the scalp, by an non invasive method, showed high reproducibility. Prolonged latency (156%) and a marked amplitude enhancement (371%) characterized the mid-latency SEPs following 64 days methadone treatment of healthy rats. Experimental diabetes induced significant alteration of both parameters; amplitude decrease of earlier components (Nl, P2) and delayed latency of later ones (P3). Two months methadone treatment of diabetic rats not only leads to the recovery but also augmented P2 (P25) amplitude (225%). It was concluded that no essential differences exist in the methadone effect on control (healthy) and diabetic Wistar female rats.

Ključne riječi

Hrčak ID:

136712

URI

https://hrcak.srce.hr/136712

Posjeta: 485 *