Pregledni rad

Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis

NATALIJA DEDIĆ PLAVETIĆ DEDIĆ PLAVETIĆ orcid.org/0000-0003-0505-4756 ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Kišpatićeva 12, 10000 Zagreb, Croatia
MARINA BARIĆ1 BARIĆ ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia
LADA BRADIĆ1 BRADIĆ ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia
ANA KULIĆ ; Department of Oncology, Division of Pathophysiology and Experimental Oncology, University Hospital Center, Zagreb, Croatia
STJEPKO PLEŠTINA ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia

Sažetak

Tumor development, promotion and ability to spread depend greatly on
tumor microenvironment. Rapid growth accompanied by inadequate angiogenesis is the reason why most solid tumors contain hypoxic regions. Activation of hypoxia signaling pathways stimulates neoangiogenesis, alters tumor metabolism, promotes a more aggressive tumor behavior and significantly affects its responsiveness to therapy. Growing amount of evidence suggest that hypoxia induces transcription of tumor promoting genes leading to increased tumor cell proliferation and metastatic potential. Improved understanding of molecular pathways will enable establishment of useful prognostic and predictive factors, along with more effective treatment options.

Ključne riječi

hypoxia; solid tumor; angiogenesis; tumor microenvironment; gene expression; progression; metastasis; resistance to treatment

Hrčak ID:

138047

URI

https://hrcak.srce.hr/138047

Datum izdavanja:

30.12.2014.

Posjeta: 1.654 *