Original scientific paper
https://doi.org/10.3325/cmj.2015.56.119
Disparities and relative risk ratio of preterm birth in six Central and Eastern European centers
Chander P Arora
; International Research and Innovation Management Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Marian Kacerovsky
; Department of Obstetrics and Gynecology, Charles University,Prague and Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
Balazs Zinner
; Department of Obstetrics and Gynecology, Semmelweis University,Budapest, Hungary
Tibor Ertl
; Department of Obstetrics and Gynecology, Medical School University of Pecs, Pecs, Hungary
Iuliana Ceausu
; Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Igor Rusnak
; Department of Obstetrics and Gynecology, Slovak Medical University Hospital, Bratislava, Slovak Republic
Serhiy Shurpyak
; Department of Obstetrics and Gynecology and PerinatologyDanylo Halytskyy Lviv National Medical University, Lviv, Ukraine
Meenu Sandhu
; International Research and Innovation Management Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Calvin J Hobel
; International Research and Innovation Management Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Daniel A Dumesic
; Gynecology, David Geffen School of Medicine, University of California, Los Angeles, CA, USADepartment of Obstetrics and
Abstract
Aim To identify characteristic risk factors of preterm birth
in Central and Eastern Europe and explore the differences
from other developed countries.
Method Data on 33 794 term and 3867 preterm births
(<37 wks.) were extracted in a retrospective study between
January 1, 2007 and December 31, 2009. The study took
place in 6 centers in 5 countries: Czech Republic, Hungary
(two centers), Romania, Slovakia, and Ukraine. Data on historical
risk factors, pregnancy complications, and special
testing were gathered. Preterm birth frequencies and relevant
risk factors were analyzed using Statistical Analysis
System (SAS) software.
Results All the factors selected for study (history of smoking,
diabetes, chronic hypertension, current diabetes,
preeclampsia, progesterone use, current smoking, body
mass index, iron use and anemia during pregnancy), except
the history of diabetes were predictive of preterm
birth across all participating European centers. Preterm
birth was at least 2.4 times more likely with smoking (history
or current), three times more likely with preeclampsia,
2.9 times more likely with hypertension after adjusting for
other covariates. It had inverse relationship with the significant
predictor body mass index, with adjusted risk ratio of
0.8 to 1.0 in three sites. Iron use and anemia, though significant
predictors of preterm birth, indicated mixed patterns
for relative risk ratio.
Conclusion Smoking, preeclampsia, hypertension and
body mass index seem to be the foremost risk factors of
preterm birth. Implications of these factors could be beneficial
for design and implementation of interventions and
improve the birth outcome.
Keywords
Hrčak ID:
139303
URI
Publication date:
15.4.2015.
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