Cardiologia Croatica, Vol. 9 No. 1-2, 2014.
Stručni rad
https://doi.org/10.15836/ccar.2014.28
Ventricular extrasystole - induced cardiomyopathy.
Vedran Velagić
orcid.org/0000-0001-5425-5840
; Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Sažetak
Ventricular extrasystoles (PVC, Premature Ventricular Contraction) are a common and generally a benign phenomenon, especially in a patient with a structurally normal heart. The first study was published in 1998 which proved that medical suppression of extrasystole results in the recovery of the left ventricular function in dilatation cardiomyopathy, whereas the concept of PVC-induced cardiomyopathy (CMP) was developed. The incidence of PVCs itself is very large in population, rises with age, but we have no accurate data on the incidence of PVC-induced cardiomyopathy. The most important factor in the development of this disease is "PVC burden", but the exact definition thereof is still being discussed. Several animal models have been developed for elucidating the pathophysiology of this disease and it is probably a functional disorder that is largely reversible. In the treatment of these patients it is necessary to detect secondary causes of extrasystole and cardiomyopathy in all available ways; because the PVC-induced CMP is diagnosis of exclusion. Out of therapeutic options we have antiarrhythmic drug therapy and catheter radiofrequency (RF) ablation at disposal. There are no randomized studies that would prefer one of these options. RF ablation, with very good results in the reversion of cardiomyopathy and with a low incidence of complications, has been preferred lately. At this point, PVC-induced CMP is still too seldom recognized as a cause of non-ischemic cardiomyopathy.
Ključne riječi
premature ventricular contraction; cardiomyopathy; antiarrhythmic drug therapy; catheter radiofrequency ablation
Hrčak ID:
141149
URI
Datum izdavanja:
17.2.2014.
Posjeta: 5.181 *