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Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial

JASMINKA PERSEC orcid id orcid.org/0000-0002-3777-8153 ; Clinic for Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava,Av. G. Šuška 6, 10000 Zagreb, Croatia
MIROSLAV ZUPCIC ; Clinic for Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava, Zagreb, Croatia
ZORAN PERSEC ; Department of Urology, University Hospital Dubrava, Zagreb, Croatia
MARIO KOPLJAR ; Clinical Department of Abdominal Surgery, University Hospital Dubrava, Zagreb, Croatia


Puni tekst: engleski pdf 1.474 Kb

str. 267-271

preuzimanja: 503

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Sažetak

Background and purpose: Use of analgetics before the pain stimulus
(preventive analgesia) obstruct development of neuroplastic changes in central nervous system, and reduces pain. Furthermore, preventive analgesia can block harmful central nervous system response and inflammation as an early consequence of operation as well. Investigation hypothesis is that preoperative central clonidine will reduce systemic inflammatory stress response better than levobupivacaine.

Materials and methods:. Patients were allocated to three groups, according
to preoperative epidural use of 5 μg/kg clonidine (n=17), 0.25%
levobupivacaine (n=12) or saline as control group (n=13). Before operation, 1 h after the beginning, 1 h, 6 h, 12 h and 24 h after the operation following parameters were analyzed: procalcitonin (PCT), interleukine-6 (IL-6), C-reactive protein (CRP) and lactate.

Results: There were no significant differences between groups in age,
gender, body mass index and operation time. We demonstrated significant
reduction in PCT, IL-6, CRP and lactate levels in preoperative clonidine
group, compared to preoperative levobupivacaine group and controle group.

Conclusion. These results support importance of clonidine central effect on
pain pathways and systemic inflammatory stress response blockade.

Ključne riječi

clonidine, levobupivacaine, preoperative analgesia, systemic inflammatory stress response, epidural analgesia

Hrčak ID:

142923

URI

https://hrcak.srce.hr/142923

Posjeta: 808 *