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Vitiligo in Croatia: A Case Report

Vedrana Bulat ; Department of Dermatology and Venereology, University Hospital Center »Sestre milosrdnice«, Zagreb, Croatia
Mirna Šitum ; Department of Dermatology and Venereology, University Hospital Center »Sestre milosrdnice«, Zagreb, Croatia
Dora Madiraca ; Department of Dermatology and Venereology, University Hospital Center »Sestre milosrdnice«, Zagreb, Croatia
Kristina Majcen ; Department of Dermatology and Venereology, University Hospital Center »Sestre milosrdnice«, Zagreb, Croatia
Antea Džapo ; Department of Dermatology and Venereology, University Hospital Center »Sestre milosrdnice«, Zagreb, Croatia
Josip Ježovita ; University of Zagreb, Croatian Studies, Department of Sociology, Zagreb, Croatia


Puni tekst: engleski pdf 119 Kb

str. 1191-1194

preuzimanja: 256

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Sažetak

Vitiligo is an acquired, chronic, multifactorial disorder which involves complex interactions between genetic risk factors
and environmental triggers. It is characterized by scattered circumscribed depigmented macules and patches anywhere
on the skin that result from loss of functional melanocytes. According to our statistical data, 1.6% of the general
population in Croatia suffers from vitiligo, but varies based on region. It affects all age groups equally, with female patients
being more affected (53.95%) than male patients, and no difference in severity of vitiligo. We present a case of a sudden
onset of vitiligo vulgaris from a female patient in her twenties, treated at the Department of Dermatology and Venereology.
Her 12-year-old brother simultaneously developed acrofacial vitiligo, six months after their mother died in a car
accident. She has been previously diagnosed with type I diabetes and autoimmune endocrinopathies. The depigmented
patches covered approximately 60% of her body, with Koebner response on trauma. Although no characteristic UV fl uorescence
was detected on the affected area, histopathological and immunohistochemical analyses revealed a complete loss
of melanocytes, while Langerhans` and dermal dendritic cells replaced the DOPA-positive melanocytes. TSH levels were
elevated, and the ultrasound showed thyroid enlargement, which substantiated for a hypothyroidism therapy. Treatment
by systemic corticosteroids for a 6 month period was successful in stabilizing the disease.

Ključne riječi

pigmentation disorders, melanocytes, vitiligo, case

Hrčak ID:

147433

URI

https://hrcak.srce.hr/147433

Posjeta: 660 *