Acta clinica Croatica, Vol. 44 No. 3, 2005.
Izvorni znanstveni članak
Transcranial Sonography can Discriminate Parkinson's Disease from other Movement Disorders
Mislav Budišić
Arijana Lovrenčić-Huzjan
Zlatko Trkanjec
Marijana Lisak
Miljenka-Jelena Kesić
Vlasta Vuković
Vida Demarin
Sažetak
While nigral substance (NS) is either barely detectable or undetectable in healthy individuals, the majority of patients with Parkinson's disease (PD) display its increased echogenicity on transcranial sonography (TCS). The aim of the study was to assess the possibility of TCS to differentiate PD from other movement disorders by the measurement of NS. TCS was performed in 28 PD patients, 10 patients with movement disorders different from PD (4 with essential tremor, 2 with neuroleptic parkinsonism, 4 with cervical dystonia) and 18 age-matched healthy controls. Fifteen patients were excluded due to inappropriate temporal acoustic bone window. TCS was applied by standardized protocol; NS was displayed, encircled, and measured twice, and mean area was calculated. Mann Whitney U-test was used for between-group comparison. TCS was possible to perform in 56 of 71 (79%) subjects. NS was undetectable or barely detectable in 9 (50%) healthy controls and 2 (20%) patients with movement disorders. Median NS size in controls was 0.17 (0.16-0.21) cm2. A 0.21 cm2 cut-off margin was used for detection of hyperechogenicity. Combined hyperechogenic NS was detected in 25 (89%) PD patients , 2 (20%) patients with movement disorders and 3 (16%) healthy individuals. Study results showed a statistically significant difference in NS echogenic size between PD patients and control group (Mann Whitney u=42; p<0.001) as well as between patients with movement disorder and PD group (Mann Whitney u=23.5; p<0.001) but no significant difference between controls and patients with movement disorders (Mann Whitney u=83.0; p=0.737). Thus, assuming appropriate temporal "bone-window", the measurement of NS by use of TCS is a valuable tool in differentiating PD from other movement disorders.
Ključne riječi
Parkinson disease - diagnosis; Parkinson disease - ultrasonography; Ultrasonography, Doppler, transcranial; Neurologic examination
Hrčak ID:
14265
URI
Datum izdavanja:
1.9.2005.
Posjeta: 2.142 *