Acta clinica Croatica, Vol. 44 No. 4, 2005.
Izvorni znanstveni članak
Doppler Sonographic, Electroencephalographic and Cognitive Changes in Individuals with Cortical Cerebral Atrophy Younger than Sixty
Dževdet Smajlović
Osman Sinanović
Mirjana Vidović
Omer Ibrahimagić
Slobodan Pavlović
Senada Sarihodžić
Mirna Šahimpašić
Sažetak
The aim of the study was to investigate Doppler sonographic, electroencephalographic and cognitive changes in patients with cortical cerebral atrophy younger than 60. Sixty individuals aged 60 years and younger with cortical cerebral atrophy detected by qualitative methods on CT scan (experimental group), and 60 subjects with normal endocranial CT scan (control group) were enrolled and matched according to age, sex and education level. Mean blood flow velocities (MBFV), resistance index (RI) and pulsatility index (PI) were measured by transcranial Doppler sonography (TCD). Electroencephalography (EEG) was done with calculation of the percent frequency of electroencephalographic waves. Tests of cognitive functions were performed with Mini Mental Status Examination (MMSE) and Wechsler Memory Scale. MBFV were significantly decreased in subjects with cortical cerebral atrophy compared with the control group (p<0.0001): middle cerebral artery 53 cm/s (experimental) vs. 65 cm/s (control group); anterior cerebral artery 38 vs. 49 cm/s; posterior cerebral artery 34 vs. 39 cm/s; and basilar artery 35 vs. 43.5 cm/s. Doppler sonography measures of RI and PI showed both parameters to be considerably higher in subjects with cortical cerebral atrophy in all arteries (p<0.001). Analysis of the percent frequency of electroencephalographic waves showed a significantly higher frequency of the slow delta and theta waves in individuals with cortical cerebral atrophy than in the control group (21% vs. 5.6% and 11.5% vs. 3.7%; p<0.0001). MMSE and Wechsler Memory Scale scores were considerably lower in patients with cortical cerebral atrophy compared with the control group (26.3 vs. 29.0 and 97 vs. 125; p<0.0001). Cognitive changes were not dependent of age and sex, but did depend on education level. Accordingly, Doppler sonographic, EEG and cognitive changes in middle-aged individuals with cortical cerebral atrophy are somewhat between normal findings and findings in patients with early dementia. Long-term follow up of these individuals and periodical monitoring of cognitive status, TCD and EEG are needed.
Ključne riječi
Cognition disorders - diagnosis; Cognition disorders - ultrasonography; Electroencephalography; Dementia, vascular - diagnosis
Hrčak ID:
14289
URI
Datum izdavanja:
1.12.2005.
Posjeta: 1.302 *