Professional paper

Lamotrigine and topiramate in prophylaxis of migraine headaches

Irena Gašparić ; Opća županijska bolnica Požega
Mateja Bošković ; Opća županijska bolnica Požega

Abstract

Migraine headache is an intense, pulsating hemicrania, accompanied by photophobia, phonophobia, scintillating scotomata, vegetative
symptoms, and sometimes also by transient neurological deficits. Migraine adversely affects emotional and socio-economic life, and there
is a correlation with cerebrovascular diseases. Relief and prophylaxis of migraine attack are very important in prevention of cerebral infarction and improvement in quality of life. The paper presents our experience in the migraine prophylaxis using the 4th generation antiepileptic drugs (lamotrigine and topiramate). The objective was to determine efficacy of the anticonvulsant prophylaxis. We have analysed the number of days
without headache, quality of life estimation, effects on working capacity evaluating the absenteeism rate, and effects on pain type and intensity. The majority of the patients (95.4 %) declared that antiepileptic prophylaxis improved their migraine. A significant reduction in headache days per year was observed, and absenteeism was significantly
reduced (x2= 16.952, P<0.0001) and eliminated in 54 % of the examinees. Pain intensity and type of were also significantly reduced.

Keywords

antiepileptic drugs; migraine; prophylaxis

Hrčak ID:

149235

URI

https://hrcak.srce.hr/149235

Publication date:

9.12.2015.

Article data in other languages: croatian

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