Prethodno priopćenje
https://doi.org/10.15644/asc49/4/8
The Influence of Different Nonsteroidal Anti-Inflammatory Drugs on Alveolar Bone in Rats: An Experimental Study
Mujgan Gungor Hatipoglu
; Zavod za dentalnu maksilofacijalnu radiologiju Stomatološkog fakulteta Sveučilišta Dumlupinar, Katahya, Turska
Sermet Inal
; Zavod za ortopediju i traumatologiju Medicinskog fakulteta Sveučilišta Dumlupinar, Kutahya, Turska
Sahin Kabay
; Zavod za urologiju Medicinskog fakulteta Sveučilišta Dumlupinar, Kutahya, Turska
Muhammet Kasim Cayci
; Zavod za biologiju Fakulteta prirodnih znanosti Sveučilišta Dumlupinar Kutahya, Turska
Ayşenur Deger
; Zavod za patologiju Medicinskog fakulteta Sveučilišta Dumlupinar, Kutahya,Turska
Halil Isa Kuru
; Zavod za medicinsku laboratorijsku tehnologiju Učilišta Simav Sveučilišta Dumlupinar, Kutahya, Turska
Sayit Altikat
; Zavod za biokemiju Medicinskoga fakulteta Sveučilišta Dumlupinar, Kutahya, Turska
Gizem Akkas
; Zavod za patologiju Ministarstva zdravlja u sklopu Sveučilišta Dumlupinar i Kliničke bolnice u Kutahyi Turska
Sažetak
The aim: The aim of this study was to investigate the effect of dexketoprofen trometamol, meloxicam, diclofenac sodium on any untreated alveolar bone when they are used as drugs for another indication. Materials and Methods: Twenty eight male Spraque-Dawley rats were randomized into four groups as dexketoprofen trometamol (Group I), meloxicam (Group II), diclofenac sodium (Group III) and control group. Nonsteroidal anti-inflammatory drugs (NSAID) were administered after a fibula fracture for 10 days. Untreated alveolar bone was histopathologically examined for spongious bone density, osteoclastic density and osteoblastic density. Results: Spongious bone density was lower in study groups (Group I, group II and group III) than the control group (p<0.05). In contrast, the increase in osteoclastic density was observed in other groups apart from the control group (p<0.05). Osteoblastic density was evaluated and it was determined that group II and group III had lower results than the control group (p<0.05) but group I was equal to the control group. Conclusion: This study showed that systemically administrated NSAIDs have the potential to affect untreated alveolar bone. This should also be considered in long term use of NSAIDs.
Ključne riječi
Non-Steroidal Anti-Inflammatory Agents; Bone Remodeling; Osteoblasts; Osteoclasts; maxilla
Hrčak ID:
149807
URI
Datum izdavanja:
21.12.2015.
Posjeta: 2.439 *