Review article

TREATMENT OF SEPSIS IN NEUTROPENIC PATIENTS

VIKTOR ZATEZALO ; Merkur University Hospital, Clinical Department of Internal Medicine, Department of Hematology, Zagreb, Croatia
Njetočka Gredelj Šimec ; Merkur University Hospital, Clinical Department of Internal Medicine, Department of Hematology, Zagreb, Croatia

Abstract

Febrile neutropenia is a common and potentially fatal complication of intense cytotoxic therapy, which makes it the main cause of non-relapse mortality in patients with hematologic malignancies. Some of the patients are at risk of specifi c infections due to underlying disease of previous treatment regimens. Considering that most febrile neutropenic patients can be diagnosed with sepsis, diagnosis and treatment should be treated as septic. It is important to recognize patients at high risk since the incidence of sepsis in neutropenic patients can be signifi cantly reduced using antimicrobial prophylaxis and granulocyte growth factors. Once sepsis occurs, prompt treatment according to guidelines, individualized based on the specifi c problems of each patient, and microbiological situation can significantly reduce mortality and morbidity.

Keywords

febrile neutropenia; sepsis

Hrčak ID:

151874

URI

https://hrcak.srce.hr/151874

Publication date:

27.1.2016.

Article data in other languages: croatian

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