Izvorni znanstveni članak
Cadmium toxicity in the epithelium of the initial epididymis segment after nicotine pretreatment
M. Hrnjičević
; Institut za histologija i embriologiju, Sarajevo, Bosna i Hercegovina
A. Pleho
; Institut za patološku [iziologijus Medicinskog fakulteta u Sarajevu, Sarajevo, Bosna i Hercegovina
I. Šuško
; Institut za histologija i embriologiju, Sarajevo, Bosna i Hercegovina
H. Tanović
; Institut za histologija i embriologiju, Sarajevo, Bosna i Hercegovina
Sažetak
The paper deals with the effects of nicotine pretreatment on the occurrence of degenerative changes in the epithelium of the initial epididymis segment resulting from a single administration of a high cadmium dose. The nicotine pretreatment lasted six days. During the first three days the experimental animals were administered i.p. 1 mg/kg of nicotine water solution each, and during the following three days a dose of 2 mg/kg body weight. On the sixth day they received an injection of 4.58 mg/kg body weight of cadmium with nicotine. During the same period the control animals were given a physiological solution in the same manner. The animals were killed by decapitation twelve days after final injection. The histological sections were used for a planimetric determination of the surface areas belonging to the epitheliurn, .interstitium and Iumen of the epididymal duct and for volumetric analysis of the principal epithelial cell nuclei. Histological analysis showed prominent vacuolization of the principal cell cytoplasm, shortened stereociliae, a significantly decreased surface area belonging to the epithelium as well as a decrease in the principal cell nuclei volume as compared with control animals. The results were compared with those obtained in another experiment under identical experimental conditions following administration only of nicotine or cadmium.
Ključne riječi
Hrčak ID:
153068
URI
Datum izdavanja:
19.1.1988.
Posjeta: 1.188 *