Acta clinica Croatica, Vol. 40 No. 1, 2001.
Izvorni znanstveni članak
A Randomized, Double-Blind Trial of the Efficacy of Octreotide Acetate Administration in the Prevention of Abdominal Pain Following Therapeutic Endoscopic Retrograde Cholangiopancreatography
Marko Duvnjak
Vladimir Supanc
Velimir Šimičević
Davor Hrabar
Branko Troskot
Lea Smirčić-Duvnjak
Rajko Ostojić
Senka Radošević
Sažetak
Abdominal pain is a complication of endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (EST). The aim of this trial was to investigate the effects of octreotide acetate in the prevention of abdominal pain in patients undergoing therapeutic ERCP. A double-blind study was carried out in 209 subjects who were randomly allocated to two groups (A and B). Group A (104 patients) received 0.5 mg of octreotide acetate subcutaneously one hour prior to ERCP; and group B (105 patients) were given placebo. Patients were assessed 2 and 24 hours following endoscopy for the following parameters: presence and character of abdominal pain, requirements of analgetics. Thirty-nine (18%) patients complained of post-ERCP pain, i.e. ten in group A and 29 in group B, all of them treated with analgetics. Of the ten group A patients, symptoms of acute pancreatitis were identified in four (3.85%) patients versus ten (9.52%) patients in the control group B. The results obtained in the study seem to indicate that octreotide pretreatment significantly reduced the development of post-ERCP pain.
Ključne riječi
Cholangiopancreatograopy, endoscopic, retrograde, adverse effects; Octreotide, therapeutic use; Pancreatitis, prevention and control
Hrčak ID:
14842
URI
Datum izdavanja:
1.3.2001.
Posjeta: 1.968 *