Acta clinica Croatica, Vol. 39 No. 2, 2000.
Stručni rad
Primary Mucoepidermoid Carcinoma of the Thyroid with Aggressive Behavior - Case Report
Božo Krušlin
Hrvoje Čupić
Vladimir Bedeković
Vlado Petric
Mirko Ivkić
Mladen Belicza
Sažetak
This report describes a primary high-grade mucoepidermoid carcinoma of the thyroid in a 33-year-old male. The patient presented with a rapidly enlarging mass in the left thyroid lobe. Cytologic analysis suggested a poorly differentiated thyroid carcinoma. Total thyroidectomy was performed. On gross examination, a poorly circumscribed, gray-white tumor measuring up to 5.5 cm in the largest diameter was found. Light microscopy showed atypical, large epithelial cells forming solid islands and nests with variable, focal production of mucin and up to 5 mitotic figures per 10 high-power fields. Squamous cell foci without keratinization were also observed. Tumor cells were immunohistochemically negative for thyroglobulin and calcitonin, and positive for cytokeratin. Electron microscopy showed squamous cells with intracytoplasmic aggregates of tonofilaments, well-developed desmosomal attachments and mucous cells characterized by numerous mucin granules. Six months after the initial treatment, ipsilateral radical neck dissection revealed 25 positive out of 44 lymph nodes. Computed tomography performed a month later revealed a large tumor located behind the larynx, compressing the trachea, with retrosternal spread into the mediastinum. The patient underwent radiotherapy for a widespread metastatic disease. We think that primary thyroid mucoepidermoid carcinoma may show an aggressive clinical course.
Ključne riječi
Carcinoma - mucoepidermoid; Thyroid neoplasms; Thyroid neoplasms - pathology; Thyroidectomy
Hrčak ID:
14953
URI
Datum izdavanja:
1.6.2000.
Posjeta: 2.232 *