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Genotoxicity of sub-lethal di-n-butyl phthalate (DBP) in Nile tilapia (Oreochromis niloticus)

Aysel Çağlan Karasu Benli ; Department of Environmental Sciences, Institute of Natural and Applied Sciences, Gazi University, Teknikokullar, Ankara, Turkey
Belda Erkmen ; Department of Biology, Faculty of Science and Letters, Aksaray University, Aksaray, Turkey
Figen Erkoç ; Department of Biology Education, Gazi University, Teknikokullar, Ankara, Turkey

Puni tekst: engleski pdf 298 Kb


str. 25-30

preuzimanja: 620



This study aimed to assess genotoxicity in Nile tilapia (Oreochromis niloticus) erythrocytes after exposure to a sub-lethal concentration of 10 mg L-1 di-n-butyl phthalate (DBP) for 24 and 96 h. The results showed that mean MN frequencies in both DBP and ethyl methane-sulfonate (EMS, positive control for MN bioassay) groups were significantly different (p<0.01) with respect to control and solvent control groups, in both exposure scenarios. When analysing nuclear abnormalities, the frequency of notched nuclei was significantly different (p<0.05) but the frequencies of other subtypes did not change. The 96-h exposure led to an increase in the mean frequencies of notched nuclei, and also caused significant differences between MN frequencies in all groups (p<0.01). Our findings indicate that sub-lethal DBP concentrations when tested in controlled laboratory conditions have genotoxic potential towards Nile tilapia. Further detailed studies should be done for the determination of the environmental risk assessment for aquatic life since DBP is a high risk contaminant of freshwater and marine ecosystems.

Ključne riječi

bioassay; genotoxicity; notched nuclei; phthalates

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Podaci na drugim jezicima: hrvatski

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