Kratko priopćenje

https://doi.org/10.1515/acph-2016-0027

Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid

DAVID CALDERÓN GUZMÁN ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
NORMA OSNAYA BRIZUELA ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
MARIBEL ORTÍZ HERRERA ; Laboratorio de Bacteriología Experimental, INP, México City, México
ERNESTINA HERNÁNDEZ GARCÍA ; Laboratorio de Farmacología, INP, México City, México
GERARDO BARRAGÁN MEJÍA ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
HUGO JUÁREZ OLGUÍN ; Laboratorio de Farmacología, INP, México City, México
ARMANDO VALENZUELA PERAZA ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
JONAS ATTILUS ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México
NORMA LABRA RUÍZ ; Laboratorio de Neurociencias, Instituto Nacional de Pediatría (INP), México City, México

Sažetak

The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex. The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.

Ključne riječi

cerebrolysin; dopamine; 3-nitropropionic acid; oxidative stress

Hrčak ID:

154689

URI

https://hrcak.srce.hr/154689

Datum izdavanja:

30.9.2016.

Posjeta: 1.811 *