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Gestational diabetes mellitus seems to be associatied with inflammation

Ayla Aktulay orcid id orcid.org/0000-0002-8094-8197 ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Yaprak Engin-Ustun ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Mehmet Sahin Ozkan ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Salim Erkaya ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Mustafa Kara ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Oktay Kaymak ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Nuri Danisman ; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey


Puni tekst: engleski pdf 188 Kb

str. 475-478

preuzimanja: 590

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Sažetak

The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like protein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (±2 years) and pre-pregnancy body mass index (±2 kg/m2). The
YKL-40/CHI3L1 levels were measured, and NLR and PLR investigated. There were no statistically significant differences in maternal age, gestational age, gravidity and parity. Higher YKL-40 levels were recorded in pregnant women with GDM compared to control subjects (203 (65-300) ng/mL vs. 159.2 (14-290) ng/mL, p=0.007). NLR and PLR were significantly higher in GDM compared with control group. In conclusion, GDM is associated with high levels of YKL-40, NLR and PLR, which indicate inflammatory status.

Ključne riječi

CHI3L1 protein, human, Diabetes, gestational, Leukocyte count, Neutrophils – cytology, Lymphocytes – cytology, Blood platelets – cytology

Hrčak ID:

155436

URI

https://hrcak.srce.hr/155436

Podaci na drugim jezicima: hrvatski

Posjeta: 1.051 *