Pregledni rad

DOES PERSONALITY PLAY A RELEVANT ROLE IN THE PLACEBO EFFECT?

Nenad Jakšić orcid.org/0000-0002-5286-720X ; Department of Psychiatry, University Hospital Centre Zagreb, Croatia
Branka Aukst-Margetić ; Department of Psychiatry, University Hospital Centre Zagreb, Croatia
Miro Jakovljević ; Department of Psychiatry, University Hospital Centre Zagreb, Croatia

Sažetak

Subjective factors influencing placebo response have been a focus of numerous theoretical conceptualizations and empirical
research. One such factor, individual's personality, has been linked to different clinical conditions, their expressions and treatment
outcomes. Thus, there is little surprise many researchers have tried to identify placebo-prone personality over the years. Because of
certain methodological and conceptual issues of the earlier studies, these efforts have not been very fruitful. However, recent
scientific endeavours, facilitated by improved experimental designs and neuroimaging technology, have 'reignited the old fires'. It is
now suggested that studies exploring the placebo-related personality traits, such as optimism/pessimism, neuroticism, and novelty
seeking, need to take into account situational variables (e.g., positive or negative expectations, patient-clinician relationship) and
relevant underlying neurobiological mechanisms (e.g., endogenous opioid and dopaminergic systems). Even though many questions
still remain to be answered, such as the identification of different situational variables interacting with personality traits, exploration
and better understanding of placebo-related personality would facilitate the use of placebo in clinical practice and improve the
methodology of clinical trials.

Ključne riječi

placebo – personality - situation-personality interaction – optimism - endogenous opioids - dopamine

Hrčak ID:

159112

URI

https://hrcak.srce.hr/159112

Datum izdavanja:

4.3.2013.

Posjeta: 1.613 *