Izvorni znanstveni članak
Terbufos-sulfone exacerbates cardiac lesions in diabetic rats: a sub-acute toxicity study
Syed M. Nurulain
; Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan
Mohamed Shafiullah
; Department of Pharmacology and Therapeutics College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Javed Yasin
; Department of Internal Medicine College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Abdu Adem
; Department of Pharmacology and Therapeutics College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Juma Al Kaabi
; Department of Internal Medicine College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Saeed Tariq
; Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Ernest Adeghate
; Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Shreesh Ojha
; Department of Pharmacology and Therapeutics College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE
Sažetak
Organophosphorus compounds (OPCs) have a wide range of applications, from agriculture to warfare. Exposure to these brings forward a varied kind of health issues globally. Terbufos is one of the leading OPCs used worldwide. The present study investigates the cardiac effect of no observable dose of a metabolite of terbufos, terbufos-sulfone (TS), under nondiabetic and streptozotocin-induced diabetic condition. 100 nmol per rat (1/20 of LD50) was administered intraperitoneally to adult male Wister rats daily for fifteen days. The left ventricle was collected for ultrastructural changes by transmission electron microscopy. The blood samples were collected for biochemical tests including RBC acetylcholinesterase, creatinine kinase (CK), lactate dehydrogenase (LDH), cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides, ALT, AST, and GGT. The study revealed about 10 % inhibition of RBC-AChE in two weeks of TS treatment in non-diabetic rats whereas RBC-AChE activity was significantly decreased in diabetic TS treated rats. CK, LDH, and triglycerides were significantly higher in diabetic TS treated rats. Electron microscopy of the heart showed derangement and lesions of the mitochondria of cardiomyocytes in the TS treated groups. The present study concludes that a non-lethal dose of TS causes cardiac lesions which exacerbate under diabetic condition. Biochemical tests confirmed the ultrastructural changes. It is concluded that a non-lethal dose of TS may be a risk factor for a cardiovascular disease, which may be fatal under diabetic condition.
Ključne riječi
acetylcholinesterase; cardiac lesion; cardiotoxicity; diabetes mellitus; lipid profile; myocyte injury markers; organophosphates
Hrčak ID:
159812
URI
Datum izdavanja:
13.6.2016.
Posjeta: 1.451 *