Izvorni znanstveni članak

https://doi.org/10.20471/acc.2016.55.01.14

Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood

Maja Baretić orcid.org/0000-0002-7242-8407 ; Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Ivana Kraljević ; Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia
Ivana Pavlić Renar ; Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia

Sažetak

The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for
insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones.

Ključne riječi

Diabetes mellitus, type 1 – complications; Hypoglycemia prevention and control; Insulin – pump administration and dosage; Insulin infusion systems; Insulin pump; Adult

Hrčak ID:

161283

URI

https://hrcak.srce.hr/161283

Datum izdavanja:

1.3.2016.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.760 *