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SERUM LEVELS OF OMENTIN ARE NOT ALTERED IN DRUG-NAIVE PATIENTS WITH MAJOR DEPRESSION: A PILOT STUDY

Fatih Canan ; Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey
Osman Yildirim ; Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Mehmet Tosun ; Department of Medical Biochemistry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Nefise Kayka ; Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Taha Can Tuman ; Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Aytekin Alcelik ; Department of Internal Medicine, Abant Izzet Baysal University School of Medicine, Bolu, Turkey

Sažetak

Background: Decreased plasma levels of omentin, a relatively novel adipokine, are shown to be associated with metabolic
abnormalities and proinflammatory states. Although other adipokines such as leptin and adiponectin have been extensively
investigated in patients with major depressive disorder (MDD), no studies have evaluated omentin levels in major depression.
Therefore, this study sought to test the hypothesis that drug-naive patients with MDD would have lower serum omentin levels than a
healthy control group similar in age, sex, and body mass index.
Subjects and methods: Thirty patients with MDD (10 men) and 30 healthy control subjects (10 men) were studied. Plasma
concentration of omentin, along with other biochemical parameters, was measured after a period of fasting. The severity of
depression was determined by the Beck Depression Inventory.
Results: No significant difference was found between patients with MDD (723.3±233.8 ng/ml) and healthy comparison subjects
(670.7±351.8 ng/ml) in mean plasma concentrations of omentin (p>0.05). There was no significant correlation between plasma
omentin levels and depression severity (r=-0.147; p>0.05).
Conclusions: This is the first investigation of omentin levels in patients with MDD. The hypothesis that circulating omentin
levels would be different in depressed patients than in healthy controls is not supported by our data.

Ključne riječi

adipokines - major depression - omentin

Hrčak ID:

162027

URI

https://hrcak.srce.hr/162027

Datum izdavanja:

3.3.2014.

Posjeta: 536 *