Kratko priopćenje

https://doi.org/10.18054/pb.2016.118.2.3592

Benzothiazole Thioflavin T improves obesity-related symptoms in mice

Fatemeh Jalalvand ; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mahsa M Amoli ; Endocrinology and Metabolism Research Center Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences Tehran, Iran
Parichehreh Yaghmaei ; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Masoud Kimiagar ; National Nutrition and Food Science Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran
Azadeh Ebrahim-Habibi orcid.org/0000-0002-8993-4859 ; Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute Tehran University of Medical Sciences, Tehran, Iran

Sažetak

Background and Purposes: In order to counteract the obesity epidemics, novel therapeutics are needed. Thioflavin T (ThT) is a benzothiazole used as an amyloid probe and has other properties such as anti-aging and antihyperglycemic effects. The current study aimed at investigating its effect on obesity.

Materials and Methods: A mouse model of obesity was generated by feeding male NMRI mice with a high fat diet (HFD) for 8 weeks. After this period, mice diet was switched to normal rodent diet, and ThT was orally administered with a 12 mg/Kg dose. The treatment effect was assessed on biochemical parameters, adipokines (adiponectin and leptin), total antioxidant capacity and TNF-α. Histological investigation was made on samples taken from adipose tissue and liver.

Results and Conclusion: After receiving HFD, mice exhibited significantly increased body weight compared with a control group as well as well as abnormality in biochemical parameters. A significantly effective result was obtained on body weight, blood glucose, cholesterol and ALT serum levels which decreased in the treated group. ThT caused also a significant decrease in leptin levels and TNF-α. Furthermore, the compound led to a reduction in the size of adipose tissue cells, as well as the number of lipid droplets in hepatic tissue. In conclusion, it is suggested that ThT possess an interesting potential for being used as an anti-obesity drug, especially when considering its previously reported effects as potential anti-diabetic and anti-ageing compound.

Ključne riječi

Thioflavin T; obesity; adipocyte; leptin; adiponectin

Hrčak ID:

162220

URI

https://hrcak.srce.hr/162220

Datum izdavanja:

30.6.2016.

Posjeta: 1.742 *