Recenzija, Prikaz slučaja

PAIN MANIFESTATIONS IN SCHIZOPHRENIA - CLINICAL AND EXPERIMENTAL ASPECTS IN HUMAN PATIENTS AND ANIMAL MODELS

Iulia Antioch ; Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania
Alin Ciobica ; Department of Biology, "Alexandru Ioan Cuza" University, Iasi, Romania; Center of Biomedical Research of the Romanian Academy, Iasi Branch, Romania
Manuel Paulet ; Romanian Academy Iasi, SOP HRD/159/1.5/S/133675 Project, Iasi, Romania
Veronica Bild ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Radu Lefter ; Romanian Academy Iasi, SOP HRD/159/1.5/S/133675 Project, Iasi, Romania
Daniel Timofte ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Sažetak

Pain is a subjective phenomenon, not fully understood, which is manifesting abnormally in most of the disorders. Also, in the
case of schizophrenia, a psychiatric disorder marked by gross distortion from reality, disturbances in thinking, feeling and behavior,
pain behaves in an unpredictable manner, just like the evolution of this mental disorder.
In this way, findings on this matter are contradictory, some pleading for decreased pain perception in schizophrenia, others for
increased pain sensitivity, while there are also reports stating no differences between healthy controls and schizophrenic patients.
Still, it is now generally accepted that pain perception is impaired in various ways in schizophrenics. Nevertheless, pain is a very
important clinical issue in this population that needs to be clarified.
Throughout this paper, we are going to review these contradictory information regarding pain manifestations in the context of
schizophrenia in both human patients and animal models, emphasizing the importance of determining pain mechanism, its
particularities and evolution in the context of schizophrenic disease, so that this phenomenon could be evaluated, quantified and
controlled with the intention of obtaining a superior management for this disorder and to possibly raise hopes of higher life quality
and expectancy in patients suffering from schizophrenia. Also, we would like to raise awareness on this matter, making psychiatrists,
general practitioners, and other medical specialists more conscious of the importance of this problem, so that medical care could
improve for these patients in the future.

Ključne riječi

pain – schizophrenia - animal models - clinical pain - experimental pain

Hrčak ID:

162388

URI

https://hrcak.srce.hr/162388

Datum izdavanja:

9.6.2015.

Posjeta: 1.271 *