Medicina, Vol. 52 No. 3, 2016.
Pregledni rad
https://doi.org/10.21860/52;3_283
Descriptive and functional definition of nucleolus – a pathway to cancer therapy
Mira Krstulja
; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Gordana Đorđević
; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Irena Seili-Bekafigo
; Zavod za kliničku citologiju, KBC Rijeka,
Tamara Braut
; Klinika za otorinolaringologiju i kirurgiju glave i vrata, KBC Rijeka, Rijeka
Sažetak
Modern tumour therapy should be target specific and comprehensive. Recent clinical trials test small molecular inhibitors of transcription of ribosomal genes and activators of apoptosis. We treatise on models of activation of the suppressors of tumour growth acting in the nucleolar domain. Tumour cells demonstrate a disordered protein regulation and mutation of P53 gene which codes for a suppressor of growth. Therapy is guided by pathogenesis. Modern disease definition is based on etiopathogenesis of cell stress, wherein participate numerous organelles, including the nucleolus. Nucleus and nucleolus are forms seen on light microscopy. This presentation focuses on the description of the visible correlate of the notion of “nucleolus”. Further to this, acid non-histone proteins which gather around the transcriptional machinery of RNA polymerase I are described, and the significance of their visualisation towards the alteration of the definition of nucleolus is pointed out. Besides being a particle within the nucleoplasm and a subnuclear organelle, the nucleolus is visualized through its functional structures – the AgNORs. The AgNOR proteins have a role in nucleolar stress. The aim of this article is to discuss the nucleolar stress.
Ključne riječi
biological stress; carcinogenesis; cell nucleolus; disease; therapeutics
Hrčak ID:
163962
URI
Datum izdavanja:
1.9.2016.
Posjeta: 3.247 *