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The Role of Standard Echocardiographic Parameters in Endomyocardial Biopsy Proven Cardiac Amyloidosis

Stanko Biočić ; Department of Cardiology Clinical Hospital Dubrava Zagreb, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia
Sandra Jakšić Jurinjak ; Departmant of Cardiology, General Hospital Karlovac, Croatia
Josip Vincelj ; Department of Cardiac surgery, Clinical Hospital Dubrava Zagreb, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia
Davor Barić ; Department of Cardiac surgery, Clinical Hospital Dubrava Zagreb, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia
Spomenka Manojlović ; Department of Cardiac surgery, Clinical Hospital Dubrava Zagreb, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia
Diana Delić Brkljačić


Puni tekst: engleski pdf 2.465 Kb

str. 441-445

preuzimanja: 176

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Sažetak


Primary light-chain (AL) amyloidosis is a plasma cell dyscrasia associated with the deposition of immunoglobulin-derived amyloid in multiple organs. In the heart, this results in an infiltrative cardiomyopathy, with increased left ventricular wall thickness, normal or decreased left ventricular (LV) cavity size and congestive heart failure. Cardiac involvement is a major determinant of prognosis of AL amyloidosis. We report a patient with cardiac amyloidosis proven by cardiac biopsy, and aim to point out at transthoracic echocardiography as the hallmark of diagnostics. Echocardiography revealed increased LV thickness at 20mm, impaired LV ejection fraction (EF) at 35%, enlarged atria, transmitral deceleration time at 156 ms and increased E/A ratio at 4.25. Early diagnosis and intervention can have a significant impact on the patient’s response to treatment, especially when the underlying condition involves a malignancy or infiltrative disorder. Standard transthoracic echocardiography as a noninvasive diagnostic tool is valuable and has a significant role in diagnosis and prognosis.

Ključne riječi

cardiac amyliodosis; echocardiography; endomyocardial biopsy; infiltrative cardiomyopathy; diagnosis

Hrčak ID:

166097

URI

https://hrcak.srce.hr/166097

Datum izdavanja:

16.9.2015.

Posjeta: 566 *