Pregledni rad
https://doi.org/10.1515/aiht-2016-67-2801
Mutagenic and carcinogenic structural alerts and their mechanisms of action
Alja Plošnik
; National Institute of Chemistry Slovenia, Ljubljana, Slovenia
Marjan Vračko
; National Institute of Chemistry Slovenia, Ljubljana, Slovenia
Marija Sollner Dolenc
; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia
Sažetak
Knowing the mutagenic and carcinogenic properties of chemicals is very important for their hazard (and risk) assessment. One of the crucial events that trigger genotoxic and sometimes carcinogenic effects is the forming of adducts between chemical compounds and nucleic acids and histones. This review takes a look at the mechanisms related to specific functional groups (structural alerts or toxicophores) that may trigger genotoxic or epigenetic effects in the cells. We present up-to-date information about defined structural alerts with their mechanisms and the software based on this knowledge (QSAR models and classification schemes).
Ključne riječi
carcinogenicity; mutagenicity; software prediction; toxicophores
Hrčak ID:
166298
URI
Datum izdavanja:
22.9.2016.
Posjeta: 9.012 *