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Comparison between inhibition of acetylcholinesterase and cholinesterase by some n-methyl - and NN-dimethyl-carbamates

Vera Simeon ; Institute for Medical Research, Yugoslav Academy of Sciences and Arts, Zagreb
Elsa Reiner ; Institute for Medical Research, Yugoslav Academy of Sciences and Arts, Zagreb


Puni tekst: engleski pdf 5.517 Kb

str. 199-206

preuzimanja: 364

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Sažetak

Second order rate constants for inhibition (ka) of various sources of acetylcholinesterase (EC 3.1.1.7) and cholinesterase (EC 3.1.1.8) with seven N-methyl- and two NN-dimethylcarbamates are given in tabular form. A comparison between acetylcholinesterase and cholinesterase is presented for different stages of the time course of the reaction: at pre-steady state the comparison is based on ka values, and at steady state on the K values (apparent equilibrium constants for enzyme and inhibitor). When two enzymes are inhibited by the same compound, the difference in the degree of inhibition at steady state and pre-steady state will be greater the greater the difference in the stability of the carbamylated enzymes

Ključne riječi

Hrčak ID:

168383

URI

https://hrcak.srce.hr/168383

Datum izdavanja:

13.12.1973.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.233 *