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Croatica Chemica Acta, Vol. 89 No. 3, 2016.

Original scientific paper

https://doi.org/10.5562/cca2992

Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate

Veronika Kovač orcid id orcid.org/0000-0001-9538-6724 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Ivana Kmetič orcid id orcid.org/0000-0001-5412-7128 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Teuta Murati ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Marina Miletić ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Lidija Barišić orcid id orcid.org/0000-0003-3628-7501 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia

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Abstract

The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

ferrocene; ferrocene-resveratrol conjugate; hepatoblastoma; normal ovary cells; resveratrol

Hrčak ID:

169468

URI

https://hrcak.srce.hr/169468

Publication date:

28.9.2016.

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