Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2016.57.331
Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial
Mehrangiz Ebrahimi-Mameghani
; Nutrition Research Center, School of Nutrition, Tabriz University ofMedical Sciences, Tabriz, Iran
Haleh Jamali
; Student Research Committee School of Nutrition, TabrizUniversity of Medical SciencesTabriz, Iran
Reza Mahdavi
; Nutrition Research Center, School of Nutrition, Tabriz University ofMedical Sciences, Tabriz, Iran
Farzad Kakaei
; Department of General Surgery, School of Medicine, Tabriz University of Medical Sciences,Tabriz, Iran
Rana Abedi
; Student Research Committee, School of Nutrition, Tabriz University of Medical Sciences Tabriz, Iran
Bita Kabir-Mamdooh
; 6Student Research Committee School of Nutrition, TabrizUniversity of Medical Sciences,Tabriz, Iran
Sažetak
Aim To investigate if conjugated linoleic acid supplementation
(CLA) affects metabolic factors and oxidative stress
in non-alcoholic fatty liver disease (NAFLD).
Methods The study was a randomized, controlled clinical
trial conducted in specialized and subspecialized clinics of
Tabriz University of Medical Sciences from January 2014 to
March 2015. 38 obese NAFLD patients were randomly allocated
into either the intervention group, receiving three
1000 mg softgel of CLA with a weight loss diet and 400 IU
vitamin E, or into the control group, receiving only weight
loss diet and 400 IU vitamin E for eight weeks. Dietary data
and physical activity, as well as anthropometric, body composition,
metabolic factors, and oxidative stress were assessed
at baseline and at the end of the study.
Results Weight, body composition, and serum oxidative
stress, insulin, and lipid profile significantly improved
in both groups, while hemoglobin A1c (HbA1c) levels
(P = 0.004), total cholesterol to high density lipoprotein
ratio (P = 0.008), low density lipoprotein to high density
lipoprotein ratio (LDL/HDL) (P = 0.002), and alanine aminotransferase
to aspartate aminotransferase (ALT/AST) ratio
(P = 0.025) significantly decreased in the intervention group.
At the end of the study, fat mass (P = 0.001), muscle mass
(P = 0.023), total body water (P = 0.004), HbA1c (P < 0.001),
triglycerides (P = 0.006), LDL/HDL ratio (P = 0.027), and ALT/
AST ratio (P = 0.046) were significantly better in the CLA
group than in the control group.
Conclusion CLA improved insulin resistance, lipid disturbances,
oxidative stress, and liver function in NAFLD. Therefore,
it could be considered as an effective complementary
treatment in NAFLD.
Ključne riječi
Hrčak ID:
170175
URI
Datum izdavanja:
15.8.2016.
Posjeta: 1.055 *