Izvorni znanstveni članak
Neutrophil to Lymphocyte ratio of Synthetic Cannabinoid Intoxication
Gökhan İnangil
; Department of Anesthesiology Gulhane Military Medical Academy Haydarpasa Training Hospital Istanbul, Turkey
Sažetak
Synthetic cannabinoids represent an increasingly popular trend, and acute intoxication is widely seen in emergency rooms and intensive care units (ICU), as they are inexpensive and easily accessible. Cannabinoids mediate their effects through binding specific receptors which are members of the G protein coupled receptor superfamily. Cannabinoid-2 receptors are primarily found in the immune system and mediate immunosuppression by inducing apoptosis, inhibition of proliferation and suppression of cytokine and chemokine production. Many studies have discussed the effects of cannabinoids on the hematological and immune systems but controversial results have been reported. The aim of this study was to identify laboratory findings of acute synthetic cannabinoid intoxication. Forty-two patients, admitted to the ‘Anesthesia intensive care unit’ between 2014 and 2015 with synthetic cannabinoid intoxication, were studied retrospectively to assess the relationship between synthetic cannabinoid intoxication and complete blood count (white blood cells (WBC), neutrophils, lymphocytes, monocytes, eosinophils, basophils) and neutrophil to lymphocyte ratio. WBC neutrophil count decreased at ICU discharge when compared to ICU admission (p<0.001). The ratio of neutrophils to lymphocytes was also lower at ICU discharge when compared to ICU admission (p<0.05).
Ključne riječi
synthetic cannabinoids; intoxication; neutrophil to lymphocyte ratio
Hrčak ID:
170191
URI
Datum izdavanja:
1.9.2016.
Posjeta: 1.845 *