Veterinarski arhiv, Vol. 86 No. 6, 2016.
Izvorni znanstveni članak
Erythromycin attenuates contractile responses of isolated urinary bladders of hyperthyroid rats.
Abdullah Karaca
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, Afyonkarahisar, Turkey
Sinan Ince
orcid.org/0000-0002-1915-9797
; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Afyon Kocatepe, Afyonkarahisar, Turkey
Sažetak
The present study was undertaken to determine the effects of erythromycin on urinary bladder muscle contractions in hyperthyroid rats. Totally 12 rats were assigned into 2 groups (6 rats in each group), as the control and hyperthyroid rat groups. The contractile responses were determined as Emax and pD2 of carbachol (10-3-10-8 M) and potassium (1-6×10-2 M, KCl) in the absence and presence of erythromycin (10-3; 5×10-4; 10-4 M). The contractile responses to carbachol (10-3-10-8 M) in the presence of verapamil (10-8 M), atropine (10-8 M), or in calcium-free Krebs solution were also determined in the absence and presence of erythromycin (10-3 M). Treatment of erythromycin significantly reduced the response to carbachol and KCl-evoked contractions. Carbachol-evoked contractions were reduced in the presence of atropine, whereas the atropineresistant components of carbachol-evoked contractions were not inhibited in the presence of erythromycin. The contractile response to carbachol was reduced in calcium-free Krebs solution and 10-8 M verapamil. In addition, when erythromycin was added together with verapamil 10-8 M, the contractile response to carbachol was inhibited. In conclusion, erythromycin more effectively inhibited urinary bladder contractions in hyperthyroid rats than the control rats, through calcium movement inhibition.
Ključne riječi
erythromycin; hyperthyroid; urinary bladder; contraction; inhibition; rat
Hrčak ID:
170223
URI
Datum izdavanja:
22.11.2016.
Posjeta: 905 *