Liječnički vjesnik, Vol. 134 No. 3-4, 2012.
Pregledni rad
IS HYPERTRIGLYCERIDAEMIA A RISK FACTOR FOR CORONARY HEART DISEASE?
Željko Reiner
Diana Muačević-Katanec
Davor Katanec
Eugenia Tedeschi-Reiner
Sažetak
Although it is still not clear whether elevated serum triglycerides are directly atherogenic or not, the results of many studies indicate that they are undoubtedly an important risk factor /biomarker for coronary heart disease (CHD). Therefore, targeting hypertriglyceridaemia should be beneficial for subjects at high risk for CHD. Elevated triglycerides are often accompanied with low HDL cholesterol, particularly in high risk patients with diabetes type 2 and/or metabolic syndrome. Such a disturbance is called atherogenic dyslipidaemia and has an increasing prevalence. The treatment of hypertriglyceridaemia has to be focused primarily on intensive lifestyle changes (weight reduction in obesity, reduction of alcohol consumption as well as reduction of added sugars, fructose and trans-fatty acids, regular aerobic physical activity) by which reduction of up to 50% in triglycerides can be achieved. Subjects with high CHD risk who cannot lower hypertriglyceridaemia by lifestyle measures should be treated with pharmacological therapy. The available medications include fibrates, niacin and prescription omega-3 polyunsaturated fatty acids. If LDL cholesterol is elevated too, combination therapy is needed. Based upon recent studies in such patients a combination of a statin with fenofibrate and/or omega-3 fatty acids can be recommended.
Ključne riječi
Coronary Disease – etiology, blood, prevention and control; Triglycerides – blood, metabolism; Cholesterol, HDL – blood; Cholesterol, LDL – blood; Hypertriglyceridemia – complications, blood, therapy; Dyslipidemias – complications, blood, therapy; Hypolipidemic agents – therapeutic use; Risk factors
Hrčak ID:
172410
URI
Datum izdavanja:
30.4.2012.
Posjeta: 2.933 *