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The Molecular Structure of cis-4-Aza-A-homo-tetrahydro-a-santonin and trans-4- Aza- A- homo- tetrahydro-a-santonin Related to the Lactam Rule

Hiroaki Takayanagi ; School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku Tokyo 108, Japan
Ikuyo Hara ; School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku Tokyo 108, Japan
Motoaki Goto ; School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku Tokyo 108, Japan
Haruo Ogura ; School of Pharmaceutical Sciences, Kitasato University, Shirokane, Minato-ku Tokyo 108, Japan

Sažetak

Stereochemistry of the titled compounds was determined by X-ray structure analysis. The seven-membered lactam rings of both compounds are in a quasi-chair conformation which agrees
with the lactam rule. The mean values of the C-NH-CO-C torsion angles are -6 ° and +5°, respectively, and these values
also agree with Klyne's hypothesis.

Ključne riječi

Hrčak ID:

175383

URI

https://hrcak.srce.hr/175383

Datum izdavanja:

30.6.1989.

Posjeta: 809 *