Croatica Chemica Acta, Vol. 62 No. 2B, 1989.
Izvorni znanstveni članak
Circular Dichroism as a Tool of Investigation in the B-Z Transition of DNA
Franco Quadrifolio
; Institute of Biology, Faculty of Medicine, University of Udine, 1-33100 Udine, Italy
Sabina Cauci
; Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 1-34127, Trieste, Italy
Luigi Emilio Xodo
; Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 1-34127, Trieste, Italy
Giorgio Manzini
; Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, 1-34127, Trieste, Italy
Sažetak
Some useful CD applications aiming to investigate the B-Z
conformational change in nucleic acids as well as their inter actions
with a ruthenium complex of potential terapeutic interest are described in this paper.
The results presented here regard:
a) the energetics of the conformational transition from the B
right-handed to the Z left-handed helix in synthetic oligodeoxynucleotides with a cytosine-guanine alternating sequence;
b) The B to Z transition for sequences containing all four
canonical bases and the role of nickel ions and sodium perchlorate
in promoting this tranformation;
c) the inter action of Ru(II)(DMSO)4CI2a. compound exhibiting
a good antitumor activity in animals, with both mononucleosides
and polynucleotides.
Ključne riječi
Hrčak ID:
175523
URI
Datum izdavanja:
10.8.1989.
Posjeta: 530 *