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Simulation of Protein Adsorption. The Denaturation Correlation

J. D. Andrade ; Department of Bioengineering and Center for Biopolymers at Interfaces, University of Utah, Salt Lake City, Utah 84112, USA
J. Herron ; Department of Bioengineering and Center for Biopolymers at Interfaces, University of Utah, Salt Lake City, Utah 84112, USA
V. Hlady ; Department of Bioengineering and Center for Biopolymers at Interfaces, University of Utah, Salt Lake City, Utah 84112, USA
D. Horsley ; Department of Bioengineering and Center for Biopolymers at Interfaces, University of Utah, Salt Lake City, Utah 84112, USA


Puni tekst: engleski pdf 4.473 Kb

str. 495-503

preuzimanja: 256

citiraj


Sažetak

We suggest means to model and simulate the adsorption of simple proteins at model interfaces. We suggest that molecular computer graphics is a very powerful method with which to study initial contact and interactions of proteins with model surfaces. We present and review kinetic models for protein adsorption and briefly discuss the role of surface-induced conformational change on such models. We suggest that data on the solution denaturation of proteins may be important in estimating protein lability and stability and, together with information on the surface tension and interfacial tension behavior of proteins, will help develop hypotheses and correlations with the actual solid/liquid interface behavior.

Ključne riječi

Hrčak ID:

176373

URI

https://hrcak.srce.hr/176373

Posjeta: 432 *